Five major industries' requirements for clean room and clean room environment

In recent years, with the development of modern science and technology and the gradual deepening of a new round of industrial revolution, developed countries have implemented the strategy of re-industrialization. Digitalization and intelligent technology will profoundly change the manufacturing mode of production and form, together with new materials and innovative breakthroughs in new energy technology, which will trigger a new round of technological and industrial changes.

In recent years, with the development of modern science and technology and the gradual deepening of a new round of industrial revolution, developed countries have implemented the strategy of re-industrialization. Digitalization and intelligent technology will profoundly change the manufacturing mode of production and form, together with new materials and innovative breakthroughs in new energy technology, which will trigger a new round of technological and industrial changes.

Industrial clean technology and biological clean technology will develop rapidly with the rapid development of science and technology and industrial products, and become one of the indispensable important technical symbols of modern industrial production and scientific experiment activities.

At present, clean technology has been widely used in all walks of life or other requirements to prevent particle pollution, microbial pollution of environmental control, because there is a big gap between different walks of life and different requirements, so the content and indicators of the control environment are different. The following is a summary of the requirements of common industry clean technology.

Clean Room Requirements for Pharmaceutical Products Production

Drugs are special commodities used to prevent, treat diseases, recover and adjust body functions. Their quality is directly related to people's health and safety. If some drugs are contaminated or cross-contaminated by microorganisms and dust particles in the manufacturing process, unexpected diseases and hazards may occur.

Clean room requirements for medical applications and medical research

Industrial clean technology and industrial clean rooms are mostly used in industrial environment control represented by integrated circuits, while biological clean rooms are mostly used in medicine to control microbial pollution. In the bio-clean room, these microorganisms are mostly composed of bacteria and fungi. The particle size of these microorganisms is more than 0.2um. The common bacteria particle size is more than 0.5um, and most of them are attached to other material particles. Biological pollution channels are not only through the air, but also related to the human body and the clothing of operators.

In the field of medical research, biological laboratories, aseptic laboratories and "special feeding animals" feeding rooms for biochemical and medical experiments also need to control microbial contamination.

Clean Room Requirements for Precision Machinery and Fine Chemical Products Production

With the development of science and technology, the production and processing of many industrial products put forward extremely high requirements for the dust concentration in the production environment, which requires a certain level of air cleanliness in the production environment and the control of the supply quality of various related substances required in the production process. For example, in film production, if the film is polluted by dust, the emulsion will be oxidized, the activity will be weakened, and the pH value will change, thus affecting the photosensitivity of the film.

Clean Room Requirements for Semiconductor and Integrated Circuit Production

Purification of conductor materials is an important basis for the development of semiconductor devices. Due to the process requirements of large scale and ultra large scale integrated circuits, in order to obtain high purity silicon materials, high purity of raw materials and intermediate media and cleanliness of production environment have become a prominent problem affecting product quality. The yield of integrated circuit chips is related to the defect density of the chips, and the defect density of the chips is related to the number of particles in the air.

Therefore, the rapid development of integrated circuits requires not only the control of particle size in the air, but also the further control of particle number. At the same time, the control of chemical pollution in VLSI production environment also has related requirements.

Clean room requirements for cosmetics and food production

Most modern cosmetics contain proteins, vitamins, amino acids, plant extracts and so on. These components provide favorable conditions for the breeding and reproduction of microorganisms such as bacteria and fungi. Therefore, microbial contamination is a shadow.

An important factor in the quality of loud cosmetics. The control objects of cleanrooms used in cosmetics production are mainly dust particles and microorganisms, which are similar to the requirements of cleanrooms used in pharmaceutical production. At present, the air cleanliness grade of cleanrooms for cosmetics production can be carried out according to GMP standard of drugs.

In the production process of food factories, the strict management of facilities is an important means to ensure the safety and hygiene of food and prevent food poisoning caused by pathogenic coliform bacteria and Salmonella or mixed with fungi in beverages. Since 1990s, WHO and some developed countries have introduced HACCP (Hazard Analysis Key Control Point) system, and formulated a food production recognition system using health management production process.

Clean rooms are closely related to electronics, pharmaceuticals, bioengineering, health care, food, cosmetics and military industries. They provide a controlled environment to meet production needs and directly affect the quality of products. However, due to the different requirements for cleanliness of clean rooms in different industries, relevant standards should be observed in the design of clean rooms to ensure that the clean environment meets the required standards.